ProteanFect® —— 作為全球首款基于內(nèi)源蛋白凝聚體技術(shù)開發(fā)的轉(zhuǎn)染試劑，正以前所未有的性能突破難轉(zhuǎn)細(xì)胞壁壘。它不僅高效攻克了T、B、NK、HSC、iPSC及神經(jīng)元等原代細(xì)胞，更在Jurkat、THP-1、K562等“血液系統(tǒng)難轉(zhuǎn)細(xì)胞系”及各類實(shí)體瘤細(xì)胞中表現(xiàn)卓越。

ProteanFect®不僅支持mRNA、siRNA、DNA等多種核酸分子的常規(guī)基因功能研究，更深度適配RNP（核糖核蛋白）介導(dǎo)的基因編輯體系。憑借其優(yōu)異的線性放大能力ProteanFect®能夠滿足從微量預(yù)實(shí)驗(yàn)到大規(guī)模驗(yàn)證的全流程，為學(xué)術(shù)研究提供穩(wěn)健的底層技術(shù)支撐。

以下是近期發(fā)表的研究成果，展示了ProteanFect®在不同科研領(lǐng)域及細(xì)胞類型中的卓越表現(xiàn)：

題目：CD160 dictates anti-PD-1 immunotherapy resistance by regulating CD8⁺ T cell exhaustion in colorectal cancer

細(xì)胞：小鼠原代CD160? CD8? T細(xì)胞

目的：siRNA敲低基因

試劑盒：PT03

題目：Mycobacterium tuberculosis-derived linoleic acid increases regulatory T cell function to promote bacterial survival within macrophages

細(xì)胞：小鼠原代CD4⁺ Treg細(xì)胞

目的：siRNA敲低基因

試劑盒：PT03

題目：High fructose consumption aggravates inflammation by promoting effector T cell generation via inducing metabolic reprogramming

細(xì)胞：小鼠原代CD4⁺ T細(xì)胞

目的：Cas9 mRNA與sgRNA共轉(zhuǎn)敲除基因

試劑盒：PT06

題目：H2A.Z primes an epigenetic landscape for memory CD8+ T cell recall response

細(xì)胞：人原代CD8? T細(xì)胞

目的：Cas9 mRNA與sgRNA共轉(zhuǎn)敲除基因

試劑盒：PT05

題目：Spatially resolved multi-omics of human metabolic dysfunction-associated steatotic liver disease

細(xì)胞：THP1細(xì)胞

目的：siRNA敲低基因

試劑盒：PT01

題目：Phosphorylation of shiftless is important for inhibiting the programmed?1 ribosomal frameshift

細(xì)胞：Jurkat細(xì)胞

目的：質(zhì)粒過表達(dá)基因

試劑盒：PT01

題目：Ginsenoside F3 alleviates T cell exhaustion via RIPOR2-mediated immunometabolic reprogramming to potentiate anti-PD-1 therapy

細(xì)胞：小鼠原代CD8⁺ T細(xì)胞

目的：siRNA敲低基因

試劑盒：PT03

題目：Single-nucleus RNA sequencing illuminates a functional analog of lymphoid organ in crustacean

細(xì)胞：Jurkat細(xì)胞

目的：質(zhì)粒過表達(dá)基因

試劑盒：PT01

題目：Fatty acid uptake mediated by FABP4 promotes the formation of CD8+T cell senescence through lipid peroxidation in the adipocyte-rich microenvironment of Ovarian Cancer

細(xì)胞：小鼠原代CD8⁺ T細(xì)胞

目的：siRNA敲低基因

試劑盒：PT03

題目：Cord blood natural killer cell-derived extracellular vesicles inhibit Zika virus infectivity through ITGB2/perforin-mediated envelope disruption in vitro and in vivo

細(xì)胞：臍帶血NK細(xì)胞

目的：siRNA敲低基因

試劑盒：PT02

題目：Single-round evolution of RNA aptamers with GRAPE-LM

細(xì)胞：Jurkat細(xì)胞

目的：spCas9-GFP蛋白與sgRNA共轉(zhuǎn)敲除基因

試劑盒：PT08

ProteanFect®轉(zhuǎn)染試劑盒，不僅是你攻克實(shí)驗(yàn)難關(guān)的得力工具，更已成為眾多科研人發(fā)表高質(zhì)量文獻(xiàn)的“助推器”。

華雅思創(chuàng)生物作為西湖凝聚體的授權(quán)合作伙伴，為您提供西湖凝聚體ProteanFect系列產(chǎn)品，歡迎聯(lián)系華雅思創(chuàng)客服咨詢購(gòu)買